For those who prefer using a keystroke rather than making a selection with the mouse, PC*MILER provides shortcut keys for commonly-used options.
| KEY(S) | FUNCTION |
| F1 | Open the ALK Support Center for help with a feature. |
| F2 | Open the Places panel. |
| Alt+F2 | Open the Route Modifiers panel. |
| F3 | Open a list of state/country abbreviations in the ALK Support Center. |
| Alt+F3 | Invoke the Route Options dialog for the active route. |
| F4 | Generate a Comparison Report. |
| F5 | Display the Detailed Route Report for the active window. |
| F6 | Display the State/Country Distance Report. |
| F7 | Insert a stop above the one highlighted on the stop list. |
| F8 | Delete the stop that is highlighted on the stop list. |
| Alt+F8 | Delete all stops in the route window. |
| F10 | Generate routes and distances (“Run” in the route window). |
| Alt+F10 | Optimize the stop order for an optimal route. |
| Alt+Bkspace | Undo typing in any entry field. |
| Ctrl+S | Save the active route with the existing filename. |
| Ctrl+Shift+S | Save the active route with a new filename. |
| Ctrl+C | Copy the open report to the clipboard for use with another program. |
| Ctrl+N | Open a new route. |
